Joseph Holt is an English brewer of beer, founded in 1849 and remaining in the same family for six generations. The company is based in Manchester and owns 127 pubs in Greater Manchester and the North West. Its beers are supplied to over 500 locations nationally Joseph Holt have brewed on their site in the Cheetham area, to the north of Manchester city centre, since 1860. Ale and lager malts are now delivered in bulk loads and stored in silos while speciality malts continue to be delivered in sacks. Between 15 and 500 barrels (4, 500 – 150, 000 pints) can be brewed per day, and a hopback is still in use, along with traditional whole leaf hops, to collect and clarify wort after boiling. All ales are top fermented in enclosed square fermenters using the historic Joseph Holt yeast strain, while lagers are fermented and conditioned in modern cylindroconical vessels. Joseph Holt have their own borehole on the brewery site to abstract brewing liquor (water) and are one of only a handful of brewers in the UK still to rack into 36 gallon casks It has a long-standing relationship with the Christie Hospital and the Holt Radium Institute in Manchester. This dates back to Sir Edward Holt, the great-grandfather of the current Chief Executive who founded the Holt Radium Institute in 1914