. La biochimica delle vitamine B. Vitamine; complesso di vitamina B. 680 LA BIOCHIMICA DI VITAMINE B Tabella 40. Inibitori competitivi di Flavin-Adenine-dinucleotide di D-amminoacido ossidasi62 . La chinina* equivalente a 37° C a 30° C Auramine 7 Atebrin 2,5 2 Novalauramine 2 chinino 1 1 chinino metacloruro 1 1 6-metossichinolina 1 1 Plasmochin 1 7-cloro-4-(4-dietilammino-l-metilbutile- ammino)-2-metilchinolina 1 7-cloro-4- (4-dietilammino- 1-metilbutile- ammino)-3-metilchinolina 0,4 0,5 7-cloro-4- (4-dietilammino- 1-metilbutile- ammino)chinolina 0,5 0,5 a-(Diamylaminomethyl)-l,2,3,4-tetraidro-
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. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. 680 THE BIOCHEMISTRY OF B VITAMINS Table 40. Competitive Inhibitors of Flavin-Adenine-Dinucleotide for D-Amino Acid Oxidase62 . Quinine Equivalent* At 37° C At 30° C Auramine 7 Atebrin 2.5 2 Novalauramine 2 Quinine 1 1 Quinine methochloride 1 1 6-Methoxyquinoline 1 1 Plasmochin 1 7-Chloro-4-(4-diethylamino-l-methylbutyl- amino)-2-methylquinoline 1 7-Chloro-4- (4-diethylamino- 1-methylbutyl- amino)-3-methylquinoline 0.4 0.5 7-Chloro-4- (4-diethylamino- 1-methylbutyl- amino)quinoline 0.5 0.5 a-(Diamylaminomethyl)-l, 2, 3, 4-tetrahydro- 9-phenanthrenemethanol Sulfathiazole Sulfapyridine Sulfadiazine Sulfanilamide Benzenesulfonamide N- (4-Diethylamino-1 -methylbutyl)-/3- (p-dimethylaminophenyl)alanine Aniline Pyridine 0L-a-(p-Dimethylaminophenyl)glycine * The ratio of concentrations of quinine and inhibitor required to give the same amount of inhibition at any concentration of flavin-adenine-dinueleotide. active as quinine. The sulfonamides are considerably less effective. The dissociation of the coenzyme from D-amino acid oxidase does not occur readily at 30° C, but dissociation is readily detectable at 37° C. At the latter temperature, the inhibitions resulting from quinine appear to be reversible and competitive with the coenzyme. The dissociation constants for two different enzyme preparations are 4.6 X 10 7 and 6.9 X 10 7 for the enzyme complex and 4.6 X 1(H and 8.9 X 1(H for the quinine-apoenzyme complex. With atebrin, two types of inhibition appear to exist. One is (CH3)2—N+=< =C—<f -N(CH3)2 ci:7X=/ I =J NH2 auramine C2H5 0.07 0.2 0.04 0.04 0.015 0.07 0.015 0.04 0.04 0.04 0.01 0.02 0.007 0.03 0.007. NH—CH—CH2—CH, —CH2—N I CH3 C2H6 plasmochin. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original work.. Williams, Roger J
