. La rivista americana delle scienze mediche. Somiglianza alla struttura alveolare è il morestriking se le cellule hanno subito ammorbidimento mucoide, o sono diventate Med.-Chir. Trans., vol. Serie 2d xxi. 1856, pag. 121. = op. Cit. Pag. 256. 1879.] Grossolano, sarcoma delle ossa lunghe. 29 oscurato da alterazioni grasse avanzate. In altri esempi la sostanza interceliirica è scarsamente granulare, gelatinosa, o anche fibrosa. Le cellule giganti stesse, che sono sinonimi delle cellule madri di Miiller e degli osteoclasti di Kolliker, sono molto simili ai thosefound normalmente nel medulla delle ossa crescenti, specialmente

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. The American journal of the medical sciences. likeness to alveolar structure is the morestriking if the cells have undergone mucoid softening, or have become Med.-Chir. Trans., 2d ser. vol. xxi. 1856, p. 121. = Op. cit. p. 256. 1879.] Gross, Sarcoma of the Long Bones. 29 obscured by advanced fatty changes. In other examples the intercelhihirsubstance is dimly granular, gelatinous, or even fibrous. The giant-cells themselves, which are synonymous with the mother-cells of Miiller and the osteoclasts of Kolliker, are very similar to thosefound normally in the medulla of growing bones, especially in the spongysubstance, where they are present in greatest number on the surface or atthe point of contact of the marrow with the osseous tissue. Like thelatter, they are made up of finely granular protoplasm, in which manyround or ovoid nuclei are contained ; but they differ from them in theirrelatively large size, sometimes reaching the enormous diameter of ^^oor even 5^* in tlie greater number and clearness of their nuclei, which Fiff. 2.. are rendered more apparent by the addition of acetic acid, and in thevariety and oddity of their forms, which it is impossible to describe.The contour of the cells seems to be influenced by the density of theintercellular substance, being irregularly spherical, ovoid, or lobulated, when the latter is soft, and provided with numerous filiform, branched, orclavated processes, through which contiguous cells are occasionally united, when it is fibroid, in consequence of the protoplasm extending itself intothe interstices of the fibrillue. They also not infrequently present areddish-brown discoloration, to which the peculiar tint of the tumour ofwhich they form a part is in some degree due. Although, as has been stated, large multinucleated cells are found in tliemedulla of the spongy substance, and, indeed, in the cambium layer of theperiosteum and in a similar layer which lines the central medullary canaPof actively growing bones, the origin

Parole chiave associate all'immagine

• bookcentury1800
• booksubjectmedicine
• bookyear1828